Tuesday, March 24, 2015

Someone Complains about Abuse by Partner, but Attacks You if You Agree: How to Respond

An letter which brings up a couple of interesting issues concerning family dynamics appeared in Carolyn Hax's newspaper advice column on 3/12/15:

Dear Carolyn: My son came on a family vacation alone and confided to his parents, siblings and friends that he was unhappy in his four-year relationship. He is 34, and she is 31. They never talk, she is very needy, she does not like his family or friends and she discourages him from seeing or calling us (we live a few hours away). He said she wants all his time and all his attention. She thinks they should “be enough” for each other not to need others. I think that’s a hallmark of an abusive relationship. He decided to ask her to move out. She can’t afford to live on her own and does not want to move in with her parents, with whom she has a bad relationship. The day after he got home he called and said they are trying to work things out. But his family and friends can see the relationship has taken all the joy out of him. How do I support him when I think the relationship is toxic? I read the letter from the 24-year-old whose family hates her  boyfriend; guess I need to dial it back and not become like her family. Trying Not to Interfere, but...

On the surface, this letter seems to relate to a question I posed in a blog post on May 1, 2012, about how and when parents should stop giving advice to, and trying to guide, their adult offspring. It does relate to that issue, but it also brings up a frequently-seen situation that is far more complicated. Say adult children come to a parent complaining in the strongest of terms about a spouse or boy/girlfriend, and describes behavior by that person that borders on being abusive, or even that is unquestionably over that border. The parent naturally gets upset with the children's significant other, and starts telling their children that said other is bad for them and should be dumped post haste.

And guess what happens next? The adult children get furious with the parent about being so "judgmental" about their significant other, and begin to loudly defend him or her.

Of course, if the parents were to keep their traps shut, the adult children would conclude that the parents were unconcerned with the fact that they are being abused. I have seen many families in which an adult child is being severely abused, the adult child's parents know about it, and yet they do and say nothing at all, let alone offer to help their offspring escape from their dangerous environment. That sounds a lot worse to me than their just being "judgmental."

Before I explain what I think is happening here, there is an important side issue that is alluded to in the letter to Carolyn Hax. The adult children are apparently doing a version of this damned-if-you-do, damned-if-you don't double bind tap dance with their friends. Perhaps you know someone like this yourself. They complain and complain about someone, but if you criticize the person they are complaining about, or tell them to speak up to or even leave the person, they defend the person and get mad at you.

What should you do? Not being in the same position as the parents, a mere friend can in most instances get away with saying things that the parents could not without digging themselves into an even deeper hole. I'll provide some recommendations on how to handle that at the end of the post, but first I would like to address the question of why it is that you, as the friend, are the recipient of this behavior. The answer to this question goes right back to the issue with the parents.

When confronted with seemingly bizarre, but clearly non-psychotic, behavior such as this from otherwise intelligent people I always ask myself, what made the person this way? Why did they get into an abusive or highly problematic relationship in the first place, and why on earth are they staying in it? The answer almost invariably lies in repetitive dysfunctional family-of-origin interactions that I have described in many posts on my blogs.

When adult children put parents in the position described in the advice column repeatedly (this whole discussion usually does not apply to one-of-a-kind interactions), the real reason they do so is most frequently for one or both of the following: The parents are in abusive relationships themselves, and/or they seem to somehow get off on hearing about the relationship trials and tribulations of their offspring. Of course, the parents will deny this vehemently if they are asked about it, but therapists have ways of making them open up and tell the truth. 

In the first case, the reason the adult child gets angry when the parent attacks the child's significant other is that the child is thinking some variation of, "Well, you're putting up with abuse. How dare you criticize me for doing the same thing? Why the hell don't you follow your own damn advice?!" The latter question is in fact a very good one indeed, and must be answered in psychotherapy, usually by constructing a genogram with a therapist, before this whole problem can be solved.

In the second case, the adult child gets angry at the parent because they are covertly thinking, "You need me suffer in a bad relationship; you're miserable if I don't, and you are gleeful when I am. How dare you insincerely ask me to end the relationship?! That isn't what you really want, is it?"

In the case described in the letter to Ms. Hax, the parent signs it, "trying not to interfere, but." This, if accurate, implies that the parent is making a great effort to hold his or her tongue. In some families, the opposite situation occurs: the parents lecture the offspring incessantly about their awful choices in romantic partners. In this situation, the adult child is possibly getting angry for a third reason: The child is thinking about the parent, "you need me to be in a bad relationship so you can continue to lecture me. If I were in a good relationship, you wouldn't know what to do with yourself!"

Keeping the right facial expression while attacking your parents when they are ostensibly showing concern for you, and not saying what you are really thinking when they do this - because you are protecting them from feeling bad about their own craziness and yourself from being completely invalidated - takes practice. Suppressing the real reason for your anger and putting on this kind of a show isn't all that easy. 

So how does one get some practice before attempting to do this with one's parents? Easy: practice it with a friend, who is far less threatening and necessary to one's mental health, and probably far more forgiving as well. Therefore, people in this predicament enlist friends with whom to practice their moves.

Doing this is not necessarily a "conscious" decision, but is usually done automatically and without any deliberation. They also do the very same thing with therapists. So how to respond?

My favorite psychotherapy supervisor as a resident, Dr. Rodney Burgoyne, suggested responding with some version of, "Well, what would you tell someone to do who was telling this story to you?" The obvious answer is that the complainers themselves would tell that person to either change that relationship or get out of it. Or at least quit complaining about it if they plan to do absolutely nothing to fix their situation. 

This question usually does stop patients in their tracks, and hopefully leads to more fruitful explorations of the main issue: why they are with the problem significant other in the first place.

That usually takes some time however. The patients can sometimes dig in their heels and refuse to answer the therapist's question or address the obvious implications. Sometimes they pretend that they cannot see what the therapist is driving at. 

I have recently found a response that leads to an even quicker and more effective way to get out of the bind. It involves putting the judgmentalism where it rightly belongs: on the person complaining about the significant other. 
This is the response that I would recommend to the friends who are being covertly enlisted to help someone practice their moves. 

I would say, "Well, you certainly aren't painting a very nice picture of (insert name of the significant other)."

Of course, this statement will not in most cases help the complainer get out of his or her dangerous and/or self-destructive situation. But it probably will induce the complainers to stop putting you in this position, and go look for someone else whose responses more meet their needs. 

To strenghten your position, you might  then add something like, "Of course, I am only getting your side of the story." This statement presumes that the patient is indeed complaining about the other, and most people will not then put up an argument which subtly accuses the other person of being controlling or judgmental. It almost forces someone to explain further why they are complaining about someone but continuing to allow that someone to mistreat them. As a friend and not a therapist for such a person, however, this is not really your job.

Of course, if you do try to become their therapist or in any way continue to allow them to put you in the double bind position, then it is very likely that your friend will think that you need to be in the position they are putting you in, so they are also doing this for your benefit as well as that of their parents.

Tuesday, March 17, 2015

Adventures in the Veterans' Hospital Mental Health Clinic - Part I

Kafkaesque: of, relating to, or suggestive of Franz Kafka or his writings; especially:  having a nightmarishly complex, bizarre, or illogical quality.

Rube Goldberg machine: a contraption, invention, device or apparatus that is deliberately over-engineered or overdone to perform a very simple task in a very complicated fashion, usually including a chain reaction. The expression is named after American cartoonist and inventor Rube Goldberg (1883–1970). Over the years, the expression has expanded to mean any confusing or complicated system.

Much to my own relief, I retired recently from my part-time job at the Veteran's Affairs (VA) hospital seeing patients in the mental health outpatient clinic. While I found the patients interesting and challenging, the VA bureaucracy was at times as infuriating as one might guess. 

The Kafkaesque nature of the system in which I worked can best be illustrated by an experience I had with my picture ID card. The VA does extensive background checks on employees - as well they should - and requires fingerprinting when their identification cards get renewed every few years. 

The card contains a computer chip which allows the bearer access to the VA computer system, most notably patient electronic medical records. A few months ago, the computer chip in my ID card malfunctioned - way before its renewal date. I thought it should be no big deal to get it replaced. Yeah right. 

Not only did I have to get fingerprinted again and wait several days for them to be processed, making it extremely difficult to actually treat patients in the interim, but they also required me to produce two forms of picture identification.

The VA did not accept its own picture identification card for this purpose, which had not expired, as one of the two!

Before I go further with more bizarre stories about the place, let me make a couple of things clear. The fact that the VA is a government bureaucracy does not mean that private companies cannot be just as nuts - or even crazier. They can certainly be far more hostile. I used to work for one. As a friend of mine who worked for both of my former employers said, at least the VA bureaucracy was predictable in its crazy decision making, while the private firm we worked for was crazy but whimsical. Sort of like the Dilbert comic strip.

Let us turn to the issue that made the news: problems with scheduling patient appontments in a timely fashion. Much of the coverage in the news simply ignored the fact that an influx of new patients who are veterans of the wars in Iraq and Afghanistan has overwhelmed the VA healthcare system. There are just way more people reliant on VA than ever before. This happened without a commensurate increase in funding or staff until just recently, and there is still a lot of catching up to do.

In 2003, The VA expected to see 4.7 million veterans in its hospitals and clinics, up more than 54 percent just from 1996. The influx of newly-injured and/or mentally traumatized vets has continued every year since then as the wars dragged on, and funding of the system for the treatment of these wounded warriors did not keep up. Not even close. Frankly, the politicians who yell "support our troops" the loudest do NOT believe in supporting our troops after they leave the service.

In mental health in particular, visits to mental health clinics have skyrocketed as the military has attempted to change the "macho" culture that discouraged such visits in the past.

So what to make of the bureaucrats who kept phony schedules to hide the fact that veterans often had inordinate waits before they received an appointment? Well, when you give employees a mandate to do something as a condition of continued employment, and you don't give them the tools and resources needed to accomplish the mandate, they will naturally become passive-aggressive and do crap like that. They have no choice. 

And we know how bureaucracies treat whistleblowers, so everybody shuts up and goes about their business doing their best to get around the double bind they are all in.

To get patients seen in a timely fashion, you would think that the place would, at the very least, be very quick about putting in the appointment system the times when various doctors are available in their clinics to see and treat patients. Again you would be wrong. Whole clinic days of mine would disappear from my upcoming January schedule in the computer for an upcoming new year, and it would take two or three months of me complaining about it for the clinic times to reappear. I could not schedule anyone! 

I finally found out why it took so long. At least this is what I was told: There was just one person doing this job. Not one person for a few clinics. One person for the whole humongous medical center! 539 provider schedules, give or take.

Still, in the defense of the VA, at least part of the fault for patients not getting seen in time by a doctor may have in some cases lied with the patients. I can not speak for VA facilities in Phoenix or the rest of the country, but here is a photograph of an actual sign displayed prominently at the entrance to the VA hospital in Memphis:

In addition, at least in the mental health clinic I worked in, one of the doctors was always available to see every walk-in patient who came in without an appointment - even if they hadn't stopped near that sign to get checked in.

Furthermore, the hospital had what they called a "patient advocate's" office, where vets could complain about problems they were having getting seen. The patient advocate was usually very effective at getting them in.

If the patients described in the news media who died before they got in for an appointment were that sick, maybe they should have not just followed the instructions of the schedulers about how soon to come it. "I vas only following orderz" is not a good excuse.

Still, it is clear that the VA does tend to be a lot more concerned with looking good rather than actually doing good. For an illustrative example, a mandate came out that veterans who were diagnosed with mental trauma and post traumatic stress, either from war or military sexual assault, had to receive a certain number of psychotherapy sessions within a prescribed period of time after their initial evalutation.

The hospital administrators recently bragged in an e-mail to the department that they had met the target. 

What they actually did was to put all of these patients into group therapy, which in my experience was, in a lot of cases, next to worthless - instead of giving them the much more effective individual treatments. The VA where I worked does not have nearly enough psychologists on staff to provide individual treatment to everyone who needs it, and the ones they do have are mostly busy doing other things because they are maldistributed as well. 

For post traumatic stress disorder uncomplicated by major personality disorders, in my estimation the most effective psychotherapy treatment is something called prolonged exposure (PE), a type of desensitization treatment. Another treatment that is "empirically validated" - by which some people mean that there are some studies, no matter how pathetic, showing that it is minimally effective - is called cognitive reprocessing therapy (CPT). That in my experience is less effective for a lot of patients than PE.

Commensurate with my experience at the VA in Memphis, an article in the journal Psychiatric Services by Watts and others published in May of 2014 found out that, nationwide, the percentage of veterans who received any sessions of either PE or CPT was six percent. Six percent! But our VA bragged about fulfilling the mandate because the veterans were seen by a mental health professional the correct number of times. Well sort of seen, anyway.

More on looking good rather than doing good in upcoming posts in this series, coming soon to a blog near you.

Tuesday, March 10, 2015

Doctors, and Tales from Their Old Wives: the "Woozle Effect."

In my blogpost of 2/24/25I made fun of scientists who waste research dollars proving things that are already obvious. Some people may object that things that are thought to be obvious sometimes turn out to be false. Of course that happens, but because it happens so rarely, it tends to make the news. 

This may lead some to think such discoveries are common. They are not. As I have said, you really don't need a study to prove that the sky appears blue to non-colorblind humans at noon on a cloudless sunny day on the equator.

There is another related situation which is also quite common - scientific ideas that were thought by many to be obvious turn out, on closer inspection, not to really be obvious at all. 

And not true. They are basically old wives' tales, and are instead based on frequent citations from the scientific literature of poorly-designed studies and/or less-than-well-thought out conclusions drawn from those studies. Such ideas become urban myths.

I have written about several of these in previous posts, and there are undoubtedly dozens and dozens more, many of which I may not be aware. Some completely fictional ideas that come to mind: the human brain only works at 20% of its capacity. We are born with all the brains cells we will ever have. Debriefing for first responders (reviewing in detail what they had just witnessed during a gory disaster) helps prevent post-traumatic stress disorder. Benzodiazepine drugs like valium and xanax interfere with a behavioral treatment called systematic desensitization.

Much to my surprise, I recently learned that there is actually a name for this phenomenon. It is called the Woozle Effect

According to Wikipedia, "A Woozle is an imaginary character in the A. A. Milne book Winnie-the-Pooh, published in 1926. In chapter three, 'In Which Pooh and Piglet Go Hunting and Nearly Catch a Woozle,' Winnie-the-Pooh and Piglet start following tracks left in snow believing they are the tracks of a Woozle. 

The tracks keep multiplying. Christopher Robin then explains that they have been following their own tracks in circles around a tree."

The Wikipedia article also points out something about this phenomenon that relates to another frequent topic of this blog: groupthink. The Woozle belief persists because it serves the needs of some group of scientists, doctors, or other interest group - whether those needs are ideological, economic, or bureaucratic.

Tuesday, March 3, 2015

Book Review: "I, Mammal" by Loretta Graziano Breuning

"We mammals are curiously preoccupied with social hierarchy. You may say you don’t care about status, but if you filled a room with people who said that, they’d soon form a hierarchy based on how anti-status each person claims to be." ~ Loretta Breuning
Despite the protestations of those who like to think human beings are not part of the animal kingdom (What are we then, plants?), we have a lot in common with our fellow furry critters. Our brains have been shaped by thousands of generations of the evolution of both genes and culture.

In this fascinating book, the author focuses on something that we inherited very strongly from our biological past: our tendency to form hierarchical societies based on status. The group, and therefore our genes, survives attacks by predators and shortages of food by allowing the strongest among us to remain strong. Weaker members of the group survive by forming alliances with, and by deferring to, the strongest members of the heard.  

In human beings, because of cultural experiences and the fact that our cortexes can anticipate future consequences more so than any other mammal, status in a particular subculture may not be defined by brute strength against predators, but by a wide variety of status markers - musical talent, scientific discoveries, or even, as illustrated by the quote at the beginning of the post, by who in a group is the least outwardly concerned with what the majority of the herd thinks of status markers.

Hierarchy challenges among primates are relatively rare since the risks are often too high. However, as the so called alphas or dominant herd members - often defined by different parameters in males and females or in different primate species - show signs of weakness, such challenges become more common. Younger members of the group may begin to assert their own dominance through oppositionalism.

The animals that are close to the top of the hierarchy but not at the top - let's call them the betas - often extensively cater to the alphas and cling to their alliance with the alphas tenaciously, often at the cost of being under great stress. They tend to be the most status conscious individuals in the group, because they have the most to lose. As the author wryly observes, they're number two, so they try harder.

The author makes the case that we concern ourselves with status in response to what she calls the "happy" brain chemicals - dopamine, serotonin, oxytocin, and endorphins - which are released in very short spurts under certain environmental conditions, and induce us to do more of whatever activities seemed to promote them in the past. Our impulses to do so are not based on conscious thoughts but are automatic reactions to the activities of the more primitive part of the brain, the limbic system. While the thinking part of the brain, the cerebral cortex, can over-ride these tendencies, doing so feels extremely unpleasant is therefore most difficult.

The author admits that she is oversimplifying the roles of the "happy chemicals," and indeed is doing so drastically. These chemicals not only work together as she points out, but are involved in many different brain and bodily functions besides those to which she attributes to them. Additionally, they regulate one another in highly complicated feedback loops with input from many other chemicals such as GABA, cortisol and glutamate.

However, the simplified view is still helpful because it does provide us with an amazingly plausible understanding of some of the behavior of mammals, including ourselves, that otherwise may seem inexplicable. The author talks about how oxytocin rewards animals for sticking with the herd. Serotonin prods us to take a certain degree of risk in going out and getting our survival needs like food satisfied. 

Dopamine rewards us when we anticipate getting our needs met. Interestingly, it does not reward us after the needs have already been met, which might explain why initially thrilling experiences can suddenly "get old." Endorphins block pain, but only in situations such as when we need all of our strength to flee in order to survive.

The author emphasizes over and over again that she is describing what is happening normally within mammals, and that status behavior is often not based on conscious deliberation. The author is in favor of our endorsing our needs for status as well as being proud rather than overly humble about our accomplishments as a way of avoiding chronic dissatisfaction - which is often then blamed on members of our own status heirarchy who are higher in it than we are. However, she points out that tendency to strive for status is not right or wrong, it just is, and she is definitely not saying that it is what always should be. 

I understand why she feels the need to repeat this, as members of the habitually-offended community will miss the point the first twenty times it is made. Hower, it does make parts of the book repetitive and monotonous. But that is a minor quibble.

I learned some very interesting things from this book that I never knew. Did you know, for example, that there are 10 times more neurons connecting the brain to the eyes than the other way around? Our brain literally tells our eyes what to look for as well as what to look at among the myriad of things surrounding us in our environment.

Did you know that Gorilla fathers in the wild often search for a good family to give their daughters to - just like the people in many cultures who arrange marriages for their offspring?

The author does not discuss "schema" formation per se, but does talk about how past experiences become the dominant mode of responding automatically and without thought to the social environment between the ages of 2 and 3 - during and after the period during which the child is most dependent for survival on getting the attention of the primary caretakers. Nerve tracts formed by observing the behaviors of the parents become stronger and also develop thicker sheathes of a coating made of a substance called myelin, which greatly increases the speed of nerve conduction. 

After they are formed, these tracks then begin to function as if the individual were on autopilot. We only notice our behavior when it no longer seems to "work" on those around us. This is partly why parental behavior is so powerful in triggering our automatic repetitive behavioral responses.

Another aspect of our powerful urges to create status hierarchies is basic to the formation of neurotic (confused, conflicted, and amibivalent) behavior. This is easiest to see in dogs, but I believe it applies to kids as well. It was discussed extensively by Cesar Millan, TV's "dog whisperer."

Dogs will presume that they are the alpha animal in a household  - unless the owner acts like he or she is the alpha, and acts that way consistently. To create a neurotic dog, treat them as if they are the pack leader by catering to them, but then punish them when they act out the normal response to being a pack leader: aggression. Then follow the punishment with lots and lots of affection, which again causes the dog to feel like the alpha. Repeat over and over. The dog becomes neurotic "because it can't make sense of the social reward system" (p. 91). Readers of this blog may recognize a similar pattern that I describe when I write about problematic parenting styles.

In general, the ideas in the book apply somewhat more to automatic behaviors within a group than they do to automatic behavior between groups. As evolutionary biologist David Sloan Wilson points out, "Selfishness beats altruism within groups. Altruistic groups beat selfish groups. All else is commentary."

Evolution has also been shaped by kin groups and ethnic groups as well as by the evolution of human culture, in which the balance between collectivism and individualism has gradually evolved to favor the latter more than in past generations, as first described by Erich Fromm. These often competing forces comprise the evolutionary theory of  so-called multilevel selection.

Once again, however, oversimplifying reality can nonetheless help us understand important ideas that might otherwise be too murky.

Tuesday, February 24, 2015

Conventional Wisdom that Seems Obvious Once Again Found to be Actually True

As I did on my posts of November 30, 2011,  October 2, 2012, September 17, 2013, and June 3, 2014, it’s time once again to look over the highlights of the latest issue of one of my two favorite psychiatry journals, Duh! and No Sh*t, Sherlock. We'll take a look at the unsurprising findings published in the latest issue of No Sh*t Sherlock. My comments in bronze.

As I pointed out in those earlier posts, research dollars are very limited and therefore precious. Why waste good money trying to study new, cutting edge or controversial ideas that might turn out to be wrong, when we can study things that that are already known to be true but have yet to be "proven"? Such an approach increases the success rate of studies almost astronomically. And studies with positive results are far more likely to be published than those that come up negative.


5/28/14.  Physical activity program may reduce mobility disability in seniors.

USA Today (5/28, Painter) reports that for seniors, “losing the ability to walk a short distance often means losing independence.” Now, “researchers say they have found a treatment that, for some, can prevent that loss of mobility,” and that is “a moderate exercise program.” The Washington Post (5/28, Bahrampour) reports that the study, “called the Lifestyle Interventions and Independence for Elders and funded by the National Institute on Aging and the National Heart, Lung, and Blood Institute, was the first of its kind to test a specific regimen of regular physical activity for sedentary older people.” The Boston Globe (5/28, Kotz) “Daily Dose” blog reports that the study, published online May 27 in the Journal of the American Medical Association, “found that elderly people who walked and did basic strengthening exercises on a daily basis were less likely to become physically disabled compared to those who did not exercise regularly.” The study control group consisted of people who were instructed to take health education classes. 

I guess it's still OK for seniors to sit very, very still while posing as nude models for art students.

6/17/14. Study Shows Association Between Mental Illness Severity and Employment and Income.

More severe mental illness appears to be associated with lower employment rates in recent years, and people with serious mental illness are less likely than people with no, mild, or moderate mental illness to be employed after age 49, according to the report, “Employment Status of People With Mental Illness: National Survey Data From 2009 and 2010,” published in Psychiatric Services in Advance.

We now know for sure that employers are not always hot to hire people who are too mentally impaired to perform the work.

6/20/14. Brain Injuries Linked To Higher Risk For Headaches.

HealthDay (6/20) reports that research scheduled to be presented at the American Headache Society meeting suggests that “U.S. veterans of the Iraq and Afghanistan wars who suffered brain injuries are at a much higher risk for headaches, especially migraines.” This “study included 53 veterans who had suffered a traumatic brain injury during deployment and...53 veterans without brain injuries.” Investigators found “that all of the veterans in the brain injury group said they experienced headaches, compared with about 76 percent of those in the control group.” Eighty-nine percent of the headaches in those with brain injuries were migraines, while just 40 percent of the headaches in the control group were migraines.

Now just a minute. Bodily injuries produce pain?? Since when?

9/1/14. The relationship between premorbid body weight and weight at referral, at discharge and at 1-year follow-up in anorexia nervosa

European Child and Adolescent Psychiatry, 09/03/2014: Focker M, et al.  In this study, the relationship between pre-morbid body mass index (BMI) percentile and BMI at admission was solidly confirmed. In addition to pre-morbid BMI percentile, BMI at admission and age were significant predictors of BMI percentile at discharge. BMI percentile at discharge significantly predicted BMI percentile at 1–year follow–up. An additional analysis that merely included variables available upon referral revealed that premorbid BMI percentile predicts the 1–year follow–up BMI percentile.

Oh, I did not see it before, but I get it now. More severe disorders have a worse prognosis.

11/25/14. Talk Therapy May Prevent Suicide in High-Risk Patients

Talk therapy may decrease risk for future suicide attempts and completions in patients who have already made a previous attempt, new research suggests. 

God, I should hope so, or I'm in the wrong business!!

1/13/15. Self-injurers experience greater negative emotionality, particularly self-dissatisfaction, compared to individuals with no NSSI history.

Self-injurers also reported less positive emotion, but these effects were smaller. The pattern of results was similar when controlling for Axis I psychopathology and borderline personality disorder.

And here I thought cutters and burners did so because their joy was just soooo unbearable.

1/30/15. Repeated Blows To Head In Boxing, Martial Arts May Damage Brain.

HealthDay (1/30, Preidt) reports that research published in the British Journal of Sports Medicine “supports the notion that repeated blows to the head in boxing or the martial arts can damage the brain.” Investigators studied “93 boxers and 131 mixed martial arts experts,” as well as 22 individuals who had never suffered a head injury. “MRI brain scans and tests of memory, reaction time and other intellectual abilities showed that the fighters who had suffered repeated blows to the head had smaller brain volume and slower processing speeds, compared to non-fighters.”

So I guess I should quit beating my head against the wall trying to get researchers to actually look into things we actually do NOT already know.

1/30/15.  The US Food and Drug Administration (FDA) has approved lisdexamfetamine dimesylate (Vyvanse, Shire) to treat binge eating disorder (BED) in adults.
The drug is the first FDA-approved medication to treat this condition. "Binge eating can cause serious health problems and difficulties with work, home, and social life," said Mitchell Mathis, MD, director of the Division of Psychiatry Products in the FDA's Center for Drug Evaluation and Research. "The approval of Vyvanse provides physicians and patients with an effective option to help curb episodes of binge eating." The efficacy of Vyvanse in treating BED was shown in two clinical studies that included 724 adults with moderate to severe BED, as reported by Medscape Medical News. In the studies, participants taking Vyvanse experienced a decrease in the number of binge eating days per week and had fewer obsessive-compulsive binge eating behaviors compared with patients in a placebo group.
Shocking new finding: appetite suppressants reduce eating.
January 2015.  Alcohol, Depression potent risk factors for suicide.

BERLIN– Alcohol dependence and major depressive disorder are similarly potent yet independent risk factors for suicidal behavior, according to Dr. Philip Gorwood. Although alcohol use disorder and major depression are extremely common and often comorbid, the mechanisms by which they boost the risk for suicidal behavior are very different, he said at the annual congress of the European College of Neuropsychopharmacology.

Insert your own joke here. No prize will be awarded for best gag, but let's see what you got!

And yes, it is OK to joke even about suicide. Black humor often helps us all to squarely face up to very serious issues, and is therefore to be encouraged. 

Tuesday, February 17, 2015

The Sacrifice of One's Own Children: Abraham and Isaac

In my blog post from 1/2/2011, Of Hormones and Ethnic Conflict, I described a biological rationale for why, under some circumstances, people are not only willing to sacrifice their own lives for their kin or ethnic group, but to sacrifice the lives of their children as well. How else to understand such diverse phenomena as mothers gladly sending off their sons to war or even to be suicide bombers, female infanticide in China, and so-called honor killings in the Middle East?

The later is especially strange - fathers or brothers kill their own daughters/sisters because they have besmirched the family honor, usually through some sexual transgression - even if involuntary! Women who have been raped can suffer this fate.

The mass appeal of the Jesus story, in which God sacrifices His only son in order to save mankind from the fires of hell, is probably due to this characteristic tendency of human beings. 

In the Old Testament, there is another widely cited story of the willingness of a parent to sacrifice a child. It is the story of God ordering Abraham to sacrifice his son Isaac as a test of his faith. He is about to do the deed when God tells him he does not have to.

An interesting sidelight to this story is that in almost all artwork that depicts this incident, Isaac is portrayed as a little boy. This can be seen in the painting at the top of the post. Not so! I was surprised to recently learn that, in fact, most Biblical scholars believe, from other things in the Bible happening around the same time, that Isaac was about 37 years old!

Abraham was supposedly over 100 years old at this time, so Isaac could have undoubtedly overpowered him. What this means is that Isaac must have been just as willing to be sacrificed as his father was willing to sacrifice him. Self sacrifice and the sacrifice of children often go hand-in-hand.

The idea from evolutionary biology that covers this willingness, kin selection, is often criticize by many in that field due to what I believe to be a misinterpretation of the phenomenon. Indeed, it is quite true that many people are not willing to sacrifice themselves or their children at those times when most of the people within their peer group are. The willingness to follow the herd into sacrifice is an inherited biological tendency, not a mandate.

Group pressure to be willing to sacrifice can indeed be very powerful - often leading resistant individuals to an almost overwhelming sense of terror known as existential groundlessness or anomie as described in this post. This does not mean, however, that everyone simply must go along. The thinking parts of the brain can choose to ignore their fears and can override the biological tendency to follow the kin group.

People who resist the herd are often in danger of being attacked or even killed themselves from others from within their group who condemn their independent ways. People may give in to these threats, but they can also stand up to them even at great peril. 

Where does such courage come from? That is an interesting question, and I do not think we know the answer.

Tuesday, February 10, 2015

Dumb Hidden Assumptions in Drug Abuse Research - An Update

And do not forget the private prison system and racist people in positions of power who want to ruin the lives of as many African-American youths as possible.

In my post of November 21, 2014, I reported on a study that showed that regular adolescent marijuana use was associated with a reduced likelihood of finishing high school, among other things. The authors of the study attributed these results to marijuana essentially causing brain damage, rather than to the fact the kids who feel the need to get stoned all the time have other problems which could easily account for their poor performance. Almost none of these other problems were controlled for in the study.

I asked, "What on earth makes people who draw the conclusion that the drug was the primary cause of the lower achievement become so stupid that they don't see that frequent drug use is a sign that the teens already had emotional problems before they even started smoking - and that it was these problems that predate the drug use that were the real cause of both the drug use AND the poor performance?"

Well guess what? Two new studies show exactly what I was talking about.

First was a new, ongoing study funded by the U.K. Medical Research Council, the Welcome Trust, and the University of Bristol, whose authors had no financial conflicts of interest. It's key clinical point: Previous research findings showing poorer cognitive performance in cannabis users may have resulted from the lifestyle, behavior, and personal history typically associated with cannabis use rather than the cannabis use itself.

Occasional to moderate cannabis use at a young age was not found to be associated with detrimental effects on cognition or educational performance. It was true that adolescents with heavier use – defined in the study as self-reported lifetime use of cannabis 50 times or more by age 15 – had a modest 2.9% decrease in educational performance on a compulsory school exam given at age 15 or 16, compared with never-users. However, heavier use had no impact at all on IQ scores measured at age 15 after adjustment for potential confounding factors.

"Previous research findings showing poorer cognitive performance in cannabis users may have resulted from the lifestyle, behavior, and personal history typically associated with cannabis use rather than cannabis use itself,” said Claire Mokrysz, of University College London.

She reported on 2,612 children who had their IQ tested at ages 8 and 15. Adolescents with heavier cannabis use by age 15 had a nearly a 3-point lower IQ at that age than did never-users, after adjustment for IQ at age 8. However, upon further adjustment for maternal education, pregnancy, and early-life factors, and use of tobacco, alcohol, and other recreational drugs, the difference in IQ between heavier and never-users vanished.

Heavier users of cannabis scored an initially impressive 11% lower than never-users on the standardized educational performance exam in an unadjusted analysis. After adjustment for the potential confounders, however, the difference shrank to a modest 2.9%. 

Performance, by the way, is not the same thing as ability. Even in this study, no effort was made to control for the motivation of test subjects, or for whether they were being distracted by ongoing problems such as family chaos at home.

The authors added that the belief that cannabis is particularly harmful may detract focus from and awareness of other potentially harmful behaviors. Not to mention other more important psychological and family issues.

The second study was done by neuroscientists at the University of Colorado at Boulder and published January 28, 2015 in the Journal of Neuroscience. Its major finding: Daily marijuana use is not associated with brain shrinkage when using a like-for-like method to control for the effects of alcohol consumption on those who both drink and toke up.

Kent Hutchison, a clinical neuroscientist at the University of Colorado, Boulder, and the senior author of the study, said his team reviewed a number of scientific papers that showed marijuana causes different parts of the brain to shrink, and his team found the studies were not consistent.

"So far, there's not a lot of evidence to suggest that you have these gross volume changes" in the brain, Hutchison said. 

I wonder how often Nora Volkow and other leaders of the National Institute on Drug Abuse will discuss these two studies or even mention them in their public presentations opposing marijuana legalization. Probable answer: NEVER.